The Cx3Cr1 CreER tamoxifen inducible system is currently the only macrophage Cre strategy that will avoid KC recombination. The authors need to rethink their results with the understanding that Chil1 ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

CX3CR1+ cells form tissue-resident macrophages in the heart that protect against cardiac injury. This study reveals CX3CR1 + cells as a multipotent progenitor population contributing also to ...

In these mice, cells that have never expressed the Cx3cr1 gene are labeled with membrane-bound tdTomato (mT), and cells that have ever expressed the Cx3cr1 gene are labeled with membrane-bound GFP (mG ...

Gene set enrichment analysis of the transcriptome of resident aortic macrophages, obtained by Affimetryx, 14 and our integrated scRNA-Seq data set indeed showed that vascular macrophages of healthy ...

Objective— Dendritic cells (DCs) have recently been found in atherosclerosis-predisposed regions of arteries and have been proposed to be causal in atherosclerosis. The chemokine receptor CX3CR1 is ...

Alsheebani is one of the first adults in the world, and the first adult at the medical system, to be effectively cured of sickle cell disease using gene therapy.

CINCINNATI (Cincinnati Business Courier) - Backed by big money and aggressive plans to manufacture cutting-edge gene and cell therapies, a biomanufacturer made big promises about a revolution in ...

Experiments in mice reveal an early postnatal window of opportunity for the effective transfer of genes to blood-cell-producing haematopoietic stem cells by injecting mice with gene-carrying ...

Adeno-associated virus (AAV)–mediated gene therapy has emerged as a promising treatment for hemophilia B. Data on safety and durability from 13 years of follow-up in a cohort of patients who had ...

SpliceBio lands $135M for a new kind of eye gene therapy The startup, which is backed by the venture arms of Sanofi, Roche and Novartis, is using dual adeno-associated viruses to help overcome the ...