Microglia are specialized immune cells that make up around 10 % of all cells in the brain and spinal cord. They work by removing pathogenic bacteria, dead cells, aggregated proteins, and soluble ...

Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated ...

Doctors save baby's life with first-ever gene fix for deadly rare disease The rare genetic disease kills 50% of babies diagnosed with it by early infancy.

Differential gene expression (DGE) analysis of CX3CR1+ resident microglia and CCR2+ infiltrating cells sorted from the hypothalamus of HFD-fed mice show an enormous difference in their transcriptomic ...

Then we used SCRN to construct the gene regulatory network based on three well-recognized AD genes (APOE, CX3CR1, and P2RY12). Enrichment analysis of the regulatory network revealed significant ...

Purpose Few reliable prognostic molecular markers have been characterized for glioblastoma multiforme (GBM), considered the deadliest of human cancers. We hypothesized that genetic polymorphisms in ...

The correlation heatmap is shown as Figure 2A. 61 CX3CR1-related genes were analyzed by gene ontology functional annotation analysis. CX3CR1-related genes were mainly concentrated on intracellular ...

Mice devoid of the CCR2 gene expression exhibit markedly reduced recruitment of monocytes to sites of inflammation (14). CX3CR1, is also an important chemokine receptor for monocytes and macrophages.

Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive ...

Finding that circulating Z alpha-1 antitrypsin polymers, a feature of ZZ AAT deficiency, lower the expression of CX3CR1 on peripheral blood mononuclear cells encourages more detailed analyses on ...