Axon, maker of body cameras and the Taser stun guns used by police, faced fierce local opposition in its hometown of Scottsdale, Arizona, when it announced plans to build a new headquarters there ...

The plasma membrane calcium pumps (PMCAs) are vital ATP‐dependent transporters responsible for the expulsion of calcium ions (Ca2+) from eukaryotic cells, thereby maintaining the low resting ...

The universality of calcium as an intracellular messenger depends on its enormous versatility. Cells have a calcium signalling toolkit with many components that can be mixed and matched to create ...

Istaroxime is a dual-mechanism therapy designed to improve both systolic and diastolic cardiac function through inhibition of Na+/K+-ATPase and activation of the SERCA2a calcium pump.

An accompanying editorial highlighted the encouraging results and described istaroxime as, "a potential new approach to heart failure-cardiogenic shock in which the next frontier is not just survival, ...

Calcium removal from the cytosol occurs by the activity of the SR pump, by exchange of calcium for sodium via the sarcolemmal sodium-calcium exchanger (Na + -Ca 2+ exchanger), by mitochondrial calcium ...

US Fire Pump is live at the International Liquid Terminals Association (ILTA) Conference at the George R. Brown Convention Center in Houston—and we brought the power! 🔥💪🏼 Come visit ...

Intracellular pH must be maintained within the physiological range (7.15–7.25) to ensure cellular homeostasis. In the heart, excitation-contraction coupling is closely dependent on intracellular pH ...

Starting Your Adventure Launch Axon: Run ./axon in your terminal Choose "New Game": Select option 1 from the main menu Describe Your World: Enter a creative description of your desired adventure ...

Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA. Journal of Biological Chemistry 2017, 292 (52) , 21330-21339.

It is enriched in axon terminals and regulates neurite outgrowth, maturation of the actin cytoskeleton, and organization of the plasma membrane (12, 13, 38, 39). Its exact biochemical and behavioral ...