Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

Conclusions: The in-depth exploration and specific regulation of macrophage source and replenishment mechanisms are expected to be an effective modulator for regulating macrophage polarization within ...

The polarization response of macrophages seeded on titanium materials is influenced by multiple factors, and artificial intelligence can assist in extracting the key features of implant materials ...

On February 13, Allogene Therapeutics published new long-term follow-up data on cemacabtagene ansegedleucel, showing the investigative allogeneic chimeric antigen receptor (CAR) T-cell therapy ...

In mice, GPR65 knockout (GPR65 KO) tumors are resistant to CAR-T cell therapy in vivo, without antigen loss. Single-cell network analyses reveal that GPR65 deficiency remodels tumor interactions with ...

A limitation of CAR-M, however, is that CAR macrophages tend to ‘nibble’ on cells rather than engulfing and eating them. Therefore, enhancing whole target cell consumption is an important goal.

A CRISPR Screen method was used to find the key metabolic genes related to CAR-iMAC polarization in tumor microenvironment. It was discovered that knockout of ACOD1 (or IRG1) could improve macrophage ...

Finding ways to turn “cold” tumors “hot” remains an ambition pursued by drug developers with differing approaches – combination regimens hold particular appeal – and one up-and-comer in the effort ...

In this article, Sino Biological demonstrates how Chimeric Antigen Receptors (CARs) can be utilized in novel cancer therapies, a change from the usual application of CARs, which heavily feature T ...

A novel monocyte-derived cell therapy showed evidence of migrating from the blood to the tumor microenvironment for several solid tumor types, according to phase 1 study results.Data from the ...