In this work, replication of a specific checkpoint sequence on the primary chromosome triggers a conformational shift in RctB, relieving inhibitory binding at the secondary chromosome’s origin ...

New imaging tools reveal how within an hour of infection, the virus begins to alter our chromosomes to kick-start its own replication.

A new paper describes how scientists used the tool to identify an important role for TRIM24 in mediating telomere repair after cells divide.

Each time a cell divides, a small section of each chromosome's protective cap — the telomere — is worn away. Most cells use ...

The cold sore-causing Herpes Simplex Virus (HSV-1) hijacks human cells and reconfigures its DNA within just an hour after ...

Origin firing is the initiation of DNA replication that takes place at specialised start sites, or replication origins, where the DNA first has to be opened up and unwound, before DNA synthesis ...

A new international study presented today at the 41 st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that IVF cycles involving male partners over the age ...

A new international study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and ...

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...