Stanford researchers discovered that dialing down an overactive enzyme, LRRK2, can regrow lost cellular “antennae” in key ...

Scientists sometimes compare predicting the course of epidemics to forecasting the weather. But there's a major ...

The UCLA advance opens the door to growing other vascularized organ models, including intestines and colons, providing ...

Scientists at The Jackson Laboratory (JAX) have developed mouse models that survive premature death and enable pre-clinical ...

Inhibition of LKKR2 may rescue neurons that are dying due to a type of Parkinson’s disease that is caused by a single genetic mutation.

The NF-κB activation pathway is based on two fundamental processes. One pathway proceeds by proteolytic degradation of inhibitory IκB proteins, which retain NF-κB DNA-binding subunits in the cytosol.

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in humans now allow initial insights into non-essential human genes in which both ...

P-glycoprotein 1 (P-gp, also known as Multidrug resistance-1, Mdr1; encoded by Abcb1a and Abcb1b in mice and ABCB1 in humans) is a plasma membrane transporter that pumps xenobiotics out of cells in an ...

Abstract Patients with Alzheimer’s disease (AD) initially show temporally-graded retrograde amnesia, which gradually progresses into more severe retrograde amnesia. Although mouse models of AD have ...

In this disease model of HD, the targeted knockdown of the Htt (huntingtin) protein mRNA knockdown approach, triggers characteristic HD-related deficits, including increased cell death (acridine ...