Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

These findings offer new insights into the underlying mechanisms of neuroinflammation and therapeutic ... The MC suspensions isolated from the buffy coat and mixed with cryoprotectant were frozen for ...

This work will be of interest to those focused on defining the molecular mechanisms involved in ubiquitin ligase ... The mother liquor containing 20% (v/v) of glycerol was used as a cryoprotectant for ...

Future studies should be conducted to investigate these effects on a dose–response paradigm and to further elucidate the mechanisms underlying the ... or on well plates with cryoprotectant for the ...

A team of scientists from the Cluster of Excellence "Balance of the Microverse" has discovered a previously unknown rejuvenation mechanism in unicellular organisms. They studied unicellular ...

For many years, however, the mechanism behind this dysfunction has remained unclear. Now a team of researchers finds that this loss of immune regulation is triggered by an increase in PRDM1-S ...

For many years, however, the mechanism behind this dysfunction has remained unclear. In a new Yale-led study, a team of researchers finds that this loss of immune regulation is triggered by an ...

Researchers describe the neural processes behind how morphine relieves pain. This is valuable knowledge because the drug has such serious side effects. In a study published in Science, researchers ...

Researchers from the University of Warwick and University of Manchester developed a machine learning-based model to enhance cryoprotectant discovery. The new approach identifies molecules that prevent ...