Many cellular processes are regulated by cyclic nucleotides through their binding to and activation of protein kinase A, protein kinase G, ion channels and Epac. Recent structural insights have ...

Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nature Structural & Molecular Biology , 2024; DOI: 10.1038/s41594-024-01220-x Cite This Page : ...

OptS is predicted to synthesize a second messenger using a minimal CRISPR polymerase (mCpol) domain, a version of the polymerase domain found in Type III CRISPR systems (Cas10) that is distantly ...

Nucleotides, such as cyclic AMP (cAMP) and cyclic GMP (cGMP), function as second messengers in cell signaling pathways. They relay signals from extracellular stimuli to intracellular targets, ...

That extra bond makes cyclic nucleotides more reactive, though, and thus they were able to join together into long chains at a decent rate (about 200 hours to reach 100 nucleotides long).

Every basic biology lesson teaches that proteins are made up of combinations of 20 distinct amino acids, which are ordered in various patterns similar to words.

The cyclic GMP–AMP synthase (cGAS) enzyme binds to viral DNA, tumor DNA, or our own aberrant DNA. DNA binding activates cGAS to synthesize cyclic GMP–AMP (cGAMP) from ATP and GTP nucleotides.

Cyclic nucleotides (e.g. cAMP and cGMP) are ubiquitous second messengers which affect various cellular functions. Photoactivated adenylyl cyclase (PAC) and guanylyl cyclase rhodopsin (Rh-GC) increase ...

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27502-27508. doi: 10.1073/pnas.2015919117 ...

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