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Scientists have created an artificial RNA system that can copy itself using simple building blocks and temperature changes.
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However, DNA polymerase cannot begin forming this new chain on its own and can only add nucleotides to a pre-existing 3'-OH group. A primer is therefore needed, at which nucleotides can be added.
DNA polymerase synthesizes double-stranded DNA molecules from unwound DNA strands during replication. Even though the end products of replication and transcription are different, they both work on DNA ...