Watson and Crick's discovery of DNA structure in 1953 revealed a possible mechanism for DNA replication. ... As the double helix unwinds, it creates a loop known as the replication bubble, ...

This paper demonstrates that the mechanism of break-induced replication (BIR) is significantly different from S-phase replication, as it proceeds via a migrating bubble driven by Pif1 helicase ...

The first step in DNA replication requires the assembly of a group of proteins called the Origin Recognition Complex (ORC). Researchers have determined how the ORC assembles during the cell ...

The bubble-like mode of DNA replication can operate in non-dividing cells, which is the state of most of the body's cells, making this kind of replication a potential route for cancer formation. " ...

As the replication bubbles progress along the DNA molecule, they eventually fuse, resulting in two complete and identical DNA molecules. The dance of precision: Coordinated replication.

DNA replication and replication stress. In eukaryotes, DNA replication initiates at many replication origins that are distributed along the length of each chromosome arm. At each origin, two ...

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

DNA Replication: Within the nucleus of every cell are long strings of DNA, the code that holds all the information needed to make and control every cell within a living organism.

Cell-like bubbles that can grow and self-replicate like living ... that carry information about themselves and use this for replication, as living cells and their information-carrying DNA do.

Protein involved in balancing DNA replication and restarting found USP50 protein helps balance nuclease and helicase activity during critical processes ...