Single-strand changes in DNA occur continually as cells divide and multiply, and while layers of repair mechanisms fix most changes, some get through and become mutations.

In vivo base editing enables precise, single-nucleotide changes to DNA without double-strand breaks. A recent application in ...

A new long-read sequencing technique has helped researchers investigate how DNA mutations arise in a variety of contexts. A collaboration of researchers led by NYU Langone Health and NYU Grossman ...

However, researchers say, most mutations have their origins in DNA changes that are present in only one of the two DNA strands, and these single-strand changes, such as a mismatched G and T base ...

Insights into the persistence of DNA damage show how strand-specific interactions shape the genome-wide distribution of mutations, including the unexpected symmetry of mutations arising in the DNA ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...

The discovery may explain why cutting edge CAR T-cell therapy has managed to revolutionized treatment for blood cancer but ...

Strand-resolved mutagenicity of DNA damage and repair. Nature, 2024; ... Scientists demonstrate that DNA mutation itself may represent only a fraction the health-related ...

Alphabet Inc.’s Google DeepMind today introduced AlphaGenome, a new artificial intelligence tool that can comprehensively ...

After DNA damage, for example by chemicals, the damaged and undamaged DNA strands are separated from each other during cell division. The cells often do not repair the DNA damage immediately; the ...

For DNA to be copied, the DNA double helix must open up, and the resulting single strands—each of which serves as a template for building a new, second strand—are vulnerable to breakage. Or ...