To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

Scientists discover how cells absorb queuosine, a vital nutrient affecting memory, learning, and cancer resistance.

Human 8-oxoguanine-DNA glycosylase (hOGG1) possesses very high specificity for 8-oxoguanine (oxoG), even though this damaged base differs from normal guanine by only two atoms. Our aim was to ...

Technical Report Published: July 2000 Seamless gene engineering using RNA- and DNA-overhang cloning Vincent W. Coljee, Heather L. Murray, William F. Donahue & Kevin A. Jarrell Nature Biotechnology ...

Additionally, we found that RNA aids in double-strand break repair in both yeast and human cells, suggesting that its role in DNA repair is evolutionarily conserved across species.

We found that RNA can actively guide the repair process of double-strand breaks. It does this by binding to broken DNA ends, helping align sequences of DNA on a matching strand that isn’t broken.

Pseudoisocytosine (J), a neutral analogue of protonated cytosine, is currently the gold standard modified nucleobase in peptide nucleic acids (PNAs) for the formation of J·G-C triplets that are stable ...

At an alkaline pH, amino acids exist in both neutral and negatively charged forms, enabling them to shuttle protons in the polymerization reaction that forms RNA from ribonucleoside 2′,3′-cyclic ...

RNA, a molecular thread comprising four bases, creates the blueprint for the production of proteins from amino acids. These proteins, in turn, drive all biochemical reactions inside cells.

At an alkaline pH, amino acids exist in both neutral and negatively charged forms, enabling them to shuttle protons in the polymerization reaction that forms RNA from ribonucleoside 2′,3 ...

Amino acids helped build RNA at the dawn of life, a new study shows. The question of how life could have emerged is one of the most long-standing mysteries in science. In a new study, the lab oratory ...