For Drosophila, an international research consortium has recently published a map of all connections between all neurons in the fly brain—the so-called connectome.

New research reveals that sugar metabolism in brain cells may be a crucial defense against Alzheimer’s and related dementias.

Firstly, the anatomy of the brain and other major organs in the fly is very different from that of humans. ... Drosophila as a Model Organism. News-Medical, viewed 29 June 2025, ...

Serial section electron microscopy volume revealing the Drosophila brain structure. Image Credits: Michael Winding. The result is the model you see, looking like a slug wearing a clown wig ...

“FlyWire,” a Princeton-led team of scientists and citizen scientists, has now made a massive step toward understanding the human brain by building a neuron-by-neuron and synapse-by-synapse roadmap — ...

Together, the team has now used this brain connectome to find all the neurons that make up the circadian clock of a fly. The result: "The circadian clock in the Drosophila brain consists of at ...

More information: Neural circuit mechanisms underlying context-specific halting in Drosophila, Nature (2024). DOI: 10.1038/s41586-024-07854-7 Provided by Max Planck Florida Institute for Neuroscience ...

Research uncovered how glycogen metabolism in neurons impacts neurodegenerative diseases like Alzheimer's. Disruption in this ...

A team of Drosophila experts and enthusiasts inspected the map and corrected its errors. It took more than a decade for the scientists to produce the first high-resolution model of the fly brain.

Drosophila brain with presenilin deficits and rescued brain (IMAGE) ... Top: A fly with deficits in the presenilin gene—a model for Alzheimer’s disease—with high levels of cell death.

Janssens J, et al. Spatial transcriptomics in the adult Drosophila brain and body. eLife. 2025;13:RP92618. Jennings BH. Drosophila – a versatile model in biology & medicine. Mater Today.

About the study. To assess the effect of the drugs on behavior, starved, male, wild-type Drosophila flies were treated with optimized doses of ATX (1.5 mg/ml, n = 24), MPH (0.25 mg/ml, n = 24), or ...