Scientists have found a novel way that includes a new lab-grown material that could help slow and even reverse some of the ...

Collagens are the primary components of ECM in fibrosis. Other ECM components, including laminin, hyaluron, elastin and fibronectin are also increased during fibrogenesis.

Chronic kidney disease (CKD) is typically associated with severe fibrosis, the exact pathogenesis of which remains unclear.

A new priority research paper was published on the cover of Aging's Volume 15, Issue 20, entitled, “Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent ...

Understanding the molecular mechanisms driving extracellular matrix (ECM) remodeling in PDAC fibrosis is crucial for overcoming treatment barriers. By dissecting these signaling pathways, ...

Liver fibrosis is a progressive and potentially reversible condition that results from chronic liver damage, ... (ECM) by activated hepatic stellate cells (HSCs) and myofibroblasts.

In contrast, young cells placed on "aged" ECM began to show signs of dysfunction, even if the scaffold was soft. "This showed us that the biochemical environment around aged heart cells matters ...

Accordingly, fibrosis of the liver is now characterized (i) by an up to 10-fold increase of ECM that comprises several types of collagens, structural glycoproteins, sulfated proteoglycans ...

Insulin resistance is closely linked to ECM remodeling in peripheral tissues, where fibrosis (excess ECM deposition) impairs insulin signaling and action. Conventionally, fibrosis was believed to ...

Doctors usually diagnose cystic fibrosis (CF) in infancy or early childhood, but some people may not receive a diagnosis until adulthood if their symptoms are mild or atypical. CF is a hereditary ...