Using a chemical proteomic strategy, we identified the ubiquitin-conjugating enzyme UBCH10 as a cellular target of this benzodiazepine series. We show that an optimized benzodiazepine analogue ...

Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial ...

Enzymes catalyze chemical reactions in organisms—without which life would not be possible. Leveraging AlphaFold2 artificial ...

Leiden researchers have discovered an enzyme that helps bacteria feed on everyday plastics. This common enzyme could play a ...