The special feature of our ESP ("Enzyme Substrate Prediction") model is that we are not limited to individual, special enzymes and others closely related to them, as was the case with previous models.

Exo Therapeutics raised $78 million in series B financing to develop a new strategy for drugging enzymes. Many drugs work by blocking target enzymes’ active sites, which perform reactions like ...

The substrate the food in this picture. It needs to bind and go into the mouth, ... But if a small molecule helps an enzyme to do a new reaction, and it’s very efficient, ...

Professor Schwabe explained: "Previously our team had discovered that the activity of the enzymes in co-repressor complexes is regulated by a small molecule called inositol phosphate.

Professor Schwabe explained: "Previously our team had discovered that the activity of the enzymes in co-repressor complexes is regulated by a small molecule called inositol phosphate.

New knowledge about the mechanism of specific protein complexes in the body could help in the development of better drugs for the treatment of diseases such as cancer and Alzheimer's.

The substrate goes through a chemical reaction and changes into a new molecule called the product — sort of like when a key goes into a lock and the lock opens. Since most reactions in your body’s ...

“We thus decided to engineer this parent enzyme.” The P450 BM3 constructs lactams through intramolecular C-H amidation, she says. “The substrate is a chain-like molecule with C-H bonds and a terminal ...

Two-step nanocage: Individual enzymes (orange and green) are first attached to half-cage structures. Half cages are then assembled into full cages, where reactants are brought into close proximity ...

An experimental compound empowers an enzyme to help process acetaldehyde, a toxic metabolite of alcohol, according to new research supported by the National Institute on Alcohol Abuse and Alcoholism ...