A new hypothesis called the “quantum memory matrix” could solve long-standing physics questions, including the Black Hole Information Paradox and dark matter.

As exotoxin A, cholix toxin (71 kDa) enters eukaryotic cells via low-density lipoprotein receptor-related protein and probably other membrane receptors, and then catalyzes ADP-ribosylation of ...

Using a range of computational tools the mechanism of action of the toxins are explored, and new inhibitors targetting the NADP binding site identified using in silico docking teachniques. Together ...

Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality globally. Elevated levels of serum LDL-C (low-density lipoprotein cholesterol) represent a significant risk factor ...

Exosomes companies working in the treatment market are Innovex Therapeutics, Coya Therapeutics, EV Therapeutics, Endosome Therapy StemXO Therapeutics, Brexogen, ILIAS Biologics, Organicell ...

imageimageEarly endosome maturation requires Rab conversion and ESCRT function; however, how these processes are coordinated remains largely elusive. This study proposes that Rab conversion in both C.

Escaping the endosome: Bend lipids improve LNP mRNA delivery and gene editing Date: January 28, 2025 Source: University of Pennsylvania School of Engineering and Applied Science Summary: A new ...

Escaping the Endosome Unfortunately, even when LNPs reach their target cells, the nanoparticles are typically captured by endosomes — tiny protective sacs within the cell.

By showing that IFITM3 inhibits homotypic late endosome fusion while reinforcing heterotypic late endosome fusion, whereby late endosomes fuse with lysosomes, we provide an explanation for how IFITM3 ...

Endosome-to-TGN transport is not only occurring from tubular early endosomes, but has been reported to occur during the entire endosome maturation process and also from late endosomes (Podinovskaia et ...

The endosome has highly dynamic motility and frequently undergoes fission and fusion events to coordinate endocytic trafficking. Endosome fission has been reported to be associated with cargo sorting.