Escaping the endosome Unfortunately, even when LNPs reach their target cells, the nanoparticles are typically captured by endosomes—tiny protective sacs within the cell. If LNPs can't escape, it ...

Vicineum is an investigational locally administered recombinant fusion protein that targets EpCAM antigens on the surface of tumor cells to deliver Pseudomonas Exotoxin A.

The combination of B. thuringiensis with 10 ppm of exotoxin was additive after 3 days postexposure. Antagonism occurred in combinations of B. thuringiensis with 1 and 10 ppm of exotoxin prior to 7 and ...