Researchers in Nikolaus Rajewsky's lab at Max Delbrück Center combined high-resolution, single-cell spatial technologies to ...

“Tumors are complex ecosystems where tumor cells live in close contact with the surrounding extracellular matrix. They interact with many other cell types,” says Professor Nikolaus ...

Mammary gland fibroblasts are highly plastic and transition through distinct states during development and disease. A new ...

Researchers have shown that activation of the protein YAP, known to help cancer cells survive treatment, behaves very ...

The Incucyte ® Live-Cell Analysis System is a fully automated platform for phase contrast and two-color fluorescence imaging, ...

Understanding the process of extracellular matrix proteolysis was one of our early goals, and we found that ovarian cancer cells produce potent matrix-degrading proteases. 2 Our studies on aging and ...

recruit tumor-associated macrophages and endothelial cells, and remodel the extracellular matrix. Tumor cells acquire genetic and epigenetic lesions that promote escape from their tissue of origin.

MICVO is a first-in-concept antibody-drug conjugate (ADC) that targets Extradomain-B Fibronectin (EDB+FN), a non-cellular structural component of the tumor extracellular matrix. This is a ...