Most human monoclonal antibodies isolated from sera are IgG1 antibodies. Neutralizing capacity aside, IgG1 is the joint-most potent activator of Fc gamma receptors on immune cells, alongside IgG3.

As of 2006 there were 18 monoclonal antibodies approved for therapeutic use in US, and 14 of them were molecules of the IgG isotype. Among these, 50% are humanized IgG1 anti-bodies. The antibody ...

In a paper recently published on hLife, Chinese scientists elucidate the 3.04 Å cryo-EM structure of HSV-1 gB bound to the neutralizing antibody D48. Through structural and sequence comparison ...

Retrained generic antibodies can ... "We investigated potential COVID-19 therapeutics using computer simulations based on the X-ray crystal structure of the receptor-binding domain of SARS ...

Cell coating, assessed on staining with an isotype-specific antihuman IgG1 antibody, was only sporadically observed (in <1 percent of T cells) in a few patients. Circulating ChAglyCD3 Levels ...

“IgM is sort of the forgotten antibody,” explained senior study investigator Ruth Ruprecht, M.D., Ph.D., director of the Texas Biomed AIDS Research Program.

Efgartigimod, a human IgG1 antibody designed to decrease pathogenic IgG autoantibody levels, demonstrated efficacy and tolerability among patients with generalized myasthenia gravis, according to ...

The site-directed addition of a polymer on the antibody trastuzumab helped this cancer-fighting antibody cross the blood-brain barrier. “Those findings collectively indicate that PMPC conjugation ...

Human IgG1 Antibody Shows Promise in Myasthenia Gravis — Phase III study shows improvements in activities of daily living by Ed Susman, Contributing Writer, MedPage Today April 22, 2021 ...

This has been overcome by "humanization" of murine antibodies, which involves the transfer of complementarity determining regions (CDRs) from the murine antibody along with some adjacent framework ...