In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in ...

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

Background: The immune microenvironment of breast cancer is richly infiltrated with macrophages, yet modulation targeting macrophage polarization has failed to achieve significant clinical efficacy.

News Release 9-Apr-2025 Machine learning approach to investigating macrophage polarization on various titanium surface characteristics Peer-Reviewed Publication BMEF (BME Frontiers) image: ...

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides significant insights into the role of Lrrk2 in M1 macrophage modulation ...

The following is a summary of “m6A reader IGF2BP2 promotes M2 macrophage polarization and malignant biological behavior of bladder cancer by stabilizing NRP1 mRNA expression,” published in the July ...

Glucose-galactose malabsorption (GGM) is a rare inherited metabolic disorder that prevents the body from absorbing two simple sugars: glucose and galactose. Glucose-galactose malabsorption (GGM ...

Working with macrophages, Resolution Therapeutics faces a “unique” manufacturing challenge. They progressively lose cells as they move towards their final product. Damian Marshall, PhD, VP ...

The polarization of tissue resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to positively impact obesity and insulin resistance. Here we show that ...

Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma. Immunity, 2024; DOI: 10.1016/j.immuni.2024.04.006 ...