Analysis of metabolite and enzyme expression levels revealed that the increased lipid content of MA-GAPDH1 was due to enhanced flux of glyceraldehyde-3-phosphate to glycerate-1, 3-biphosphate.

Title of the original paper: Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization.

Glycerol-3-phosphate acyltransferases (GPAT) catalyze the first step in the synthesis of glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded by at least two ...

Abstract The purpose of these studies is to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, dedifferentiation of Müller glia (MG), reprogramming into proliferating ...

A crucial molecule for brain health acts as a garbage collector of other fat molecules (lipids), despite also being a lipid ...

Scientists have gained a deeper understanding of a molecule that regulates lipid levels in the brain. This breakthrough could ...

GlobalData’s report assesses the drugs in the 1 Acylglycerol 3 Phosphate O Acyltransferase PNPLA3 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the ...

Chen, L. (2021). Discovery of a Carbamoyl Phosphate Synthetase 1-Deficient HCC Subtype With Therapeutic Potential Through Integrative Genomic and Experimental Analysis.

BXQ-350: Modulating ceramide and sphingosine-1-phosphate for antitumor activity in patients with advanced CRC.. If you have the appropriate software installed, you can download article citation data ...