Background: TORCH (Towards a Revolution in COPD Health) is an international multicentre, randomised, placebo-controlled clinical trial of inhaled fluticasone propionate/salmeterol combination ...

Rationale Asthma is characterized by type 2 (T2) inflammation, small airway dysfunction (SAD), mucus plugging, and remodeling. Airway remodeling is poorly responsive to current therapies, contributing ...