The histone deacetylase HDAC-5, upon dephosphorylation and translocation to the nucleus, directly inhibits MEF2, preventing myogenesis.

Immunofluorescent image of human muscle fibres for Myogenesis-ISRO, showing nuclei (blue) and proteins (red). Image courtesy of Institute for Stem Cell Science and Regenerative Medicine (India).

While other types of LRAs, including oral HDAC inhibitors, have been tested in trials, none have been able to reduce the size of the HIV reservoir, according to the researchers.

SpaceX, along with Axiom Space, launched its fourth private crewed mission to the International Space Station (ISS) on Wednesday, June 25, at 2:31 AM EDT (06:31 UTC) atop Falcon 9 and the newly ...