Although the Arabidopsis thaliana RPD3-type histone deacetylase HDA19 and its close homolog HDA6 participate in SIN3-type histone deacetylase complexes, they display distinct biological roles, with ...

This review investigates the role of neuronal epigenomes as molecular mediators of brain aging and potential targets to prevent cognitive decline. It first discusses the current evidence for neuronal ...

AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clinical trials for multiple myeloma, leukemia, and lymphoma. It has few hydrogen bond donors and acceptors but is a chiral ...

One of the most salient features defining modern humans is our remarkable cognitive capacity, which is unrivaled by any other species. Although we still lack a complete understanding of how the human ...

This work was supported by funding from NIH T32 AR079114/AR/NIAMS and 1332329/EFRI/NSF. Mohammed A. Barajaa was funded by Imam Abdulrahman Bin Faisal University, Dammam, 34212, Saudi Arabia. We ...

This study, which includes additional experiments in response to the reviewer comments, presents valuable findings illustrating the role of PI3Kα in heterotopic ossification in FOP model mice. The ...