Thus, the calcineurin signaling pathway predominating in normal tissue may in fact be compromised rather than induced in the failing human heart. These experiments raise several intriguing issues.

Apr. 29, 2025 — Daily exposure to certain chemicals used to make plastic household items could be linked to more than 356,000 global deaths from heart disease in 2018 alone, a new analysis of ...

A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and ...