Amino acids play a fundamental role in regulating how cells respond to drugs. These molecules, which form proteins, act like ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Tertiary Structure of a Protein The tertiary structure of a protein is the overall 3-dimensional structure of a polypeptide also caused by interactions of the R-groups of specific amino acids. These ...

Hydrophobic amino acids are vital components in the realm of protein structure and function. While hydrophilic amino acids establish interactions with water molecules in the cellular environment, ...

Proteins are made of amino acid chains, or polypeptides. Amino acids have a basic backbone made of an amino group and a carboxyl group, and differ in their side-chains.

Given that bitterness intensity depends on the degree of hydrolysis of proteins and hydrophobic amino acid content, the polypeptides and peptides obtained had a greater molecular weight than that ...

In fixed-backbone design, researchers start from a fixed protein structure and then use an algorithm to determine what run of amino acids will fold into that shape.

In addition, a file named structure_[sequence].pdb will contain the peptide structure predicted by the conformer option in RDKit (see main publication), which will have the correct numeration and ...

Results Part One: Trypsin Versus Pepsin Digestion Complete peptide mapping of antibodies is not always feasible with trypsin when the antibody sequence results in small hydrophilic peptides that are ...

The protein has a primary structure rich in hydrophobic amino acids; it also contains substantial amounts of lysine and glutamic acid. The secondary structure is comprised of ~40% β-sheet structures, ...