In the current study, the scientists installed up to five distinct mutations on a single lambda phage genome without counterselection in only a few hours of hands-on time.

He and a colleague proved a theory advanced by the Nobel Prize winners James Watson and Francis Crick, who discovered DNA’s ...

Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction. eLife , 2023 DOI: 10.7554/eLife.91647.1 Cite This Page : ...

Coliphage lambda was effectively reactivated from five fragments in Salmonella phage P22 and E. coli, ... The team built the SP6 phage genome minus the capsid protein-encoding gene 31.

The lambda phage, for example, prefers to destroy E. coli bacteria, ... In the lysogenic cycle, the phage's DNA lives as part of the bacterium itself and both continue to reproduce as one.

In this study, they found that the lambda phage shares this mechanism. If the DNA slips to the extent that it would completely fall out, it is caught by its end and prevented from detaching from ...

This process required purification of the endonuclease and optimization of PaqCI-mediated DNA cleavage conditions for the lambda phage template DNA, an arduous process even for skilled researchers.

Esther Lederberg, the pioneering microbial geneticist whose crucial discoveries were overshadowed by those of her Nobel Prize-winning husband, Joshua Lederberg, died Nov. 11 at Stanford Hospital ...

Scientists have demonstrated a new potential way to edit the genomes of bacteria in complex environments, by equipping viruses to hunt them down and insert the CRISPR gene-editing system.