N=9-20 cells per set. (D-F) Frames from representative FRAP live-cell imaging sequences. mEmerald-tubulin-expressing MIN6 cells. Inverted grayscale images of maximum intensity projections of spinning ...

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Cell–cell interactions are of fundamental importance for cellular function. In islets of Langerhans, which control blood glucose levels by secreting insulin in response to the blood glucose ...

Additionally, the Min6 cell culture supernatant inhibits cell death induced by aggregated Aβ. Furthermore, we observed that this protective effect against Aβ toxicity is specific to pancreatic ...

Previously, we reported that hypoxia causes the downregulation of a number of β‐cell genes involved in insulin secretion in mouse islets and MIN6 β‐cells (Sato et al, 2014). However, the mechanisms of ...

Accordingly, Min6 OVE cells had higher ROS content in the mitochondria and cytosol than Min6 GK and KD cells in response to high glucose (HG, Fig 7A). However, N‐acetylcysteine (NAC), a ROS scavenger, ...

Briefly, MIN6 cells were seeded in six-well plates and cultured for 24 h, pretreated with or without glucose (33.3 mmol/L) for 24 h, and then exposed to AOS (16, 32, and 64 μg/ml) for 24 h. Then, the ...

Here, we focused on the effects of olanzapine on insulin biosynthesis and secretion by mouse insulinoma MIN6 cells. Olanzapine reduced maturation of proinsulin, and thereby inhibited secretion of ...

LC3 expression remained unchanged. Downregulation of MiD51 resulted in inhomogeneity of the mitochondrial network in MIN6 cells with hyperelongated and fragmented mitochondria. Mitochondrial membrane ...

Adenine Augmented T1r2 Expression in MIN6 Cells Figure 5 (a) shows that 1 mM adenine augmented T1r2 transcript levels of MIN 6 cells in the medium with 25 mM glucose.