Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.

Tumor associated macrophages (TAMs) are pivotal in the tumor microenvironment, influencing angiogenesis, metastasis, and immunosuppression. This study explores macrophage polarization using a ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

As antibiotic-resistant "superbugs" make infections trickier to treat, some in the medical community are turning to ...

The traditional therapeutic strategy of functionalizing repair materials with immunomodulators, drugs, and chemokines to manipulate macrophage polarization often faces challenges such as undesirable ...

M2 macrophages act as a pivotal factor in immune regulation, tissue remodeling, wound healing, and angiogenesis (27, 28). 2.2 Effects of different polarization states on AS M1 and M2 macrophages ...

Macrophages are present in all body compartments, including cancerous tissues, and their functions are profoundly affected by signals from the microenvironment under homeostatic and pathological ...

If these macrophages are treated with IFN-γ followed by LPS, they polarize to an M1 phenotype with characteristic expression of tumor necrosis factor-α and IL-12. 64 M2 macrophages were originally ...

Mitochondrial Metabolic Regulation of Macrophage Polarization in Osteomyelitis and Other Orthopedic Disorders: Mechanisms and Therapeutic Opportunities Provisionally accepted Jinglin Li 1,2 Lin Zhang ...

PG3M@GaPP promotes macrophage polarization to the anti-inflammatory M2 phenotype, enhancing immune modulation and bacterial uptake. The platform’s positive charge facilitates endosomal escape, ...