Signalling pathways implicated in M1 and M2 macrophage polarization are indicated. An initial stimulus leads to the activation of sequence-specific transcription factors that eventually mediate ...

Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most ...

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and ...

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization. Immunity , 2015; 42 (3): 419 DOI: 10.1016/j.immuni.2015.02.005 ...

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease ...

In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in ...

The understanding of how macrophages regulate their response to toxic particles via two independent pathways could uncover therapeutic opportunities to quell inflammation BIRMINGHAM, Ala ...

The study involved a comprehensive dataset constructed from 35 carefully selected academic papers, out of an initial 128, focusing on 13 features related to macrophage polarization.