Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer ...

Macrophages, which accumulate in tissues during inflammation, may be polarized toward pro-inflammatory (M1) or tissue reparative (M2) phenotypes. The balance between these phenotypes can have a ...

CD131 contributes to intestinal inflammation in ulcerative colitis, possibly by promoting the infiltration of macrophages, while targeting CD131 might potentially be a treatment remedy for ulcerative ...

The current study discovered a circulating serum protein leucine-rich alpha-2 glycoprotein 1 (LRG1) as a pivotal activator of macrophages, instigating a proinflammatory M1 polarization during ...

Coronary heart disease is caused by atherosclerosis, a cholesterol-driven inflammatory disease of the vessel wall. A hallmark of atherogenesis is the accumulation of pro-inflammatory (M1) macrophages ...

Immunometabolism is an emerging field, and to understand immune cell metabolism during inflammation and infection is of great interest. In this report, cutting edge microscopy techniques and ...

Tissue-resident and recruited macrophages play a central part in the development of inflammation and fibrosis progression in the liver. Zwicker et al. review our current understanding of macrophage ...

Inflammatory bowel disease (IBD) comprises chronic relapsing disorders of the gastrointestinal tract characterized pathologically by intestinal inflammation and epithelial injury. Here, we uncover a ...