Scientists at The Jackson Laboratory (JAX) have developed mouse models that survive premature death and enable pre-clinical ...

A research team has demonstrated that chronic hyponatremia (CHN) can directly cause anxiety-like behaviors in mice by disrupting key neurotransmitters in the brain.

A new study from UCLA Health has uncovered how inflammation in brain blood vessels exacerbates damage in vascular dementia and demonstrated that targeting this process with a repurposed drug can ...

Changes in blood–brain barrier (BBB) properties and endocannabinoid system function contribute to stress responses and have been implicated in the development of mood disorders. Here, we report ...

The present work characterizes the effects of synthetic E-cadherin peptide (HAV) on blood–brain barrier (BBB) integrity using various techniques including magnetic resonance imaging (MRI) and ...

Mechanistic discrepancies between species highlights the limitations of mouse models in advancing STING inhibition drugs for various diseases.

UC San Diego scientists have created a gene therapy that goes beyond masking Alzheimer’s symptoms—it may actually restore ...

Studies in mice have shown that this fluid flushes out waste products made by brain cells, including beta-amyloid, a protein linked to conditions such as Alzheimer’s and Parkinson’s disease.

High homocysteine levels can damage blood vessels and brain cells, worsening cognitive decline. Studies show Alzheimer’s patients often have about 30% higher homocysteine than healthy people.

Alzheimer's disease (AD) is a debilitating neurodegenerative condition that affects a significant proportion of older people ...

These vascular changes are especially concerning given their potential to contribute to ischemic strokes, which occur when blood flow to the brain is blocked, often by clots or narrowed vessels ...