Trapped immune cells laden with microplastics starve the brain of oxygen—mouse study links vascular blockages to memory loss and motor deficits, with lingering risks even after symptoms fade.

The change in blood flow that occurred with these slow waves was up to 20% of the entire brain blood supply. Surprisingly, this phenomenon was only weakly tied to changes in brain activity.

Reduced blood flow These laser speckle contrast images show blood flow in the mouse brain at various times after microplastics injection. The images indicate that blockages of microplastic-labelled ...

For the first time, however, experts succeeded in visually tracking the movement of microplastics through brain blood vessels in mice—and the pile-ups resembled a microscopic “car crash.” ...

The mice developed no inflammation in brain blood vessels, ruling that out as a mechanism. Instead, ... High-Sodium Diet Has Opposing Effects on Mean Arterial Blood Pressure and Cerebral Perfusion in ...

Microplastics sit on a human finger with an inset image of blood vessels in the brain. Svetlozar Hristov / mr.suphachai praserdumrongchai/iStock / Getty Images Plus ...

To test this, Kitazume and colleagues generated mice that expressed human APP770 specifically in their endothelial cells. These EC-APP770+ mice pumped out high levels of serum sAPP770. At two years of ...

Study Reveals Expanding and Contracting Blood Vessels in Awake Mouse Brain NIH-funded study challenges conventional wisdom about brain blood flow. News ... Broggini T, Duckworth J, Ji X, et al.

However, the limiting problem in brain gene therapy is delivery to the brain followed by regulation of the expression of the transgene. Present day gene vectors do not cross the blood-brain barrier.

Blood flow makes waves across the surface of the mouse brain Date: May 29, 2024 Source: NIH/National Institute of Neurological Disorders and Stroke ...