New research reveals that Alzheimer's disease may impair nerve function not by reducing myelin, but by altering the proteins ...

The effects of the stochastic gating properties of sodium channels on the extracellular excitation properties of mammalian nerve fibers was determined by computer simulation. To reduce computation ...

The physiological significance of the node of Ranvier is now well known. The histological delineation of its length, however, still remains uncertain. Should it be identified as the gap between the ...

Myelination and the formation of nodes of Ranvier are essential for the rapid conduction of nerve impulses along axons in the peripheral nervous system (PNS). While many animal-based and ...

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There are small gaps in the myelin coating, called nodes of Ranvier. The action potential jumps from gap to gap, allowing the signal to move much quicker.

During the transmission of electrical signals, the signal jumps from one Node or Ranvier to the next, allowing a myelin-containing fiber to transmit a signal 100 times faster than without myelin.

Arancibia-Carcamo, L. and Attwell, D. (2014) The Node of Ranvier in CNS Pathology. Acta Neuropathologica, 128, 161-175.