The nucleotide molecule cyclic AMP (cAMP) was found to act as an intermediate of hormone function 2, and another nucleotide, cyclic GMP (cGMP), was later also identified as a second messenger. The ...

mBio 2020 Aug 25;11(4):e01625-20. doi: 10.1128/mBio.01625-20. Abstract. The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second ...

Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 ...

BioRxiv (2023) PubMed PMID: 37546940; PubMed Central PMCID: PMC10402079.. Abstract. The mammalian innate immune system uses cyclic GMP–AMP synthase (cGAS) to synthesize the cyclic dinucleotide ...

c-di-GMP is an example of a nucleotide second messenger, an intracellular signal widespread in bacteria responsible for regulating crucial processes, including mobility, virulence and biofilm ...

In humans, the innate immune receptor cGAS detects viral infection to produce the nucleotide second messenger cGAMP, which initiates STING-dependent antiviral signaling. Bacteria encode predecessors ...

By Jeyashree Sundaram, MBA. Cyclic adenosine 3,5-monophosphate (cAMP) is a cyclic nucleotide that serves as a vital second messenger in several signaling pathways.

This small molecule is a potent and selective PDE-1 phosphodiesterase inhibitor that increases neuronal levels of cyclic nucleotide second messengers. Lu AF88434 is intended to enhance neuroplasticity ...

Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, ... Intriguingly, some mRNAs acquire an additional methylation at their second nucleotide.

c-di-GMP is an example of a nucleotide second messenger, an intracellular signal widespread in bacteria responsible for regulating crucial processes, including mobility, ...