The study did not show any safety concerns but failed the endpoint of a 75 per cent improvement in PASI score (Psoriasis Area and Severity Index) and EASI (Eczema Area and Severity Index) score at ...

The mean value for the 15D HRQoL measure was 0.84. For Psoriasis Area Severity Index (PASI) and DLQI, the mean values were 2.5 and 3.3, respectively. Ten patients had a PASI score >10 and 10 patients ...

Increasing the golimumab dose yielded approximately 18% and 44% improvement in DAS28-CRP and PASI scores, respectively (table 1). For details of golimumab pharmacokinetic and antibody assessments, ...

Baseline average PASI scores were 15.5, 12.4, and 12.4, respectively. Among new users, adverse event rates were 41.7% with Humira, 36.1% with Amjevita, and 42.6% with Imraldi.

Subgroup analysis showed no significant difference in the reduction of PASI scores between 320 mg q4w dosage and q8w dosage (RR = 1.00; 95% CI = 0.96–1.03).

A lower PASI when therapy ends (HR, 1.03; 95% CI, 1.01-1.05). This model had good predictive and discriminative ability. The sensitivity analysis showed similar results to the primary analysis.

The studies also looked at whether Tremfya improved IGA scores and PASI scores compared to Humira (see Table 2 below). People treated with Tremfya were more likely to have improved IGA and PASI ...

Improvements in PASI scores were seen as early as week 4 and maintained through week 12. Similarly, a PGA score of 0 or 1 was achieved by 52% of patients in the 30 mg group, compared with 4% in ...

Typically, a score of <5-10 is considered mild disease, 10-20 is considered moderate to severe, and >20 is considered to be quite severe. Evaluation of psoriasis in clinical trials is often ...

3.2 Study characteristics and quality The baseline characteristics of the included studies are shown in Table 1. The 20 studies included were conducted in 11 countries. The mean (median) PASI of the ...

The primary endpoint of the study was a reduction from baseline of at least 75 percent in the Psoriasis Area and Severity Index score (PASI 75 response) at Week 16. Study results demonstrated a ...