The chirality of tissues and organs is essential for their proper function and development. Tissue-level chirality derives from the chirality of individual cells that comprise the tissue, and cellular ...

These includes compelling evidence that the podocyte is directly affected in diabetic nephropathy with early podocyte loss and that alterations in its actin cytoskeleton are associated with ...

A: GLUT4 immunofluorescence (green) and phalloidin staining of the actin cytoskeleton (red) of insulin-treated podocytes. a: Intact cytoskeleton. b: Cytochalasin D disrupted cytoskeleton.

Cycles of controlled fasting may promote regeneration of podocytes in patients with primary glomerulonephritis, a pilot study suggests. After conducting various animal studies, Laura Perin, PhD ...

The cytoskeleton provides most cells with their shape, structure, and internal organization. In turn, the cytoskeleton relies on a type of actin protein, called filamentous or F-actin.

Cytoskeletons, made up of the protein actin, serve as structural support for cells but are also key in processes like the cell's ability to grow, divide and internalize key substances.

The podocyte actin cytoskeleton is highly dynamic and regulated by small GTPases, but the large GTPase dynamin also plays a critical role through binding to and regulating filamentous actin, which is ...

The hypothesis that podocyte loss is a culprit in the development of glomerulosclerosis was formulated more than 30 years ago 39,41 and has subsequently been proved both experimentally and ...

The podocyte actin cytoskeleton is essential for the normal functions of podocytes including their interactions with matrix and neighboring podocytes. These matrix and cell-cell interactions determine ...

From left: Uri Manor, PhD, Cara Schiavon, PhD, and Tong Zhang, PhD. [Salk Institute] “The actin cytoskeleton plays multiple critical roles in cells, from cell migration to organelle dynamics.

In a new study, University of Maryland researchers have demystified the process by which cells receive their shape—and it all starts with a protein called actin.

In the other mode (Fung et al (2019) J. Cell Sci.), mitochondrial depolarization causes rapid accumulation of an extensive ‘shell’ of actin filaments around the depolarized mitochondria, dependent on ...