C: GLUT1 immunogold localization in normal human glomerular sections. a: Section through the filtration barrier. GLUT1 is found at the podocyte cell surface and in intracytoplasmic vesicles (v).

The advent of improved cell culture techniques, the discovery of key podocyte-specific molecules, and advances in transgenic technology have revolutionized the study of podocytes in health and ...

SAN DIEGO, June 11, 2025--Travere Therapeutics today announced that the Company will present three abstracts at the upcoming International Podocyte Conference.

Podocytes are a terminally differentiated cell type located in the glomerulus. Podocyte damage and the subsequent dysregulation of podocyte proteins have been implicated in various kidney disorders.

The conditionally immortalised podocyte cell line allows an in-vitro process of maturation analogous to the development and maturation of podocytes in-vivo. The result is a homogenous, stable cell ...

Uses Toxicology studies Metabolism Therapeutic targeting Renal physiology R&D Co-culture studies (e.g. 3D culture model) Benefits Primary human cell derived (excluding murine podocyte cell line) ...

PEMP analysis confirmed that ELX-02 treatment improved podocyte foot process effacement in all three patients with an average post-treatment increase in FSD of 60% as compared to baseline levels.

Stage 5 chronic kidney disease, which heralds end-stage renal disease (ESRD) and the need for dialysis or transplantation, is a major and rapidly increasing socioeconomic burden worldwide. In 2011, ...

The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function.

LONDON, UK I July 09, 2025 I Purespring Therapeutics, a precision nephrology company focused on transforming the treatment of kidney diseases, today announces ...