Podocytes demonstrate a strong reliance on insulin to function properly, according to a study published in Cell Metabolism (2010;12:329-340).

A newly-established protocol offers hope for kidney disease modeling, drug discovery, and potential cell therapies. Previous work from the Wyss Institute at Harvard University established a protocol ...

Kidney podocytes, all grown up New protocol produces large numbers of mature human podocytes Date: July 11, 2018 Source: Wyss Institute for Biologically Inspired Engineering at Harvard ...

Podocytes are specialised cells of the renal corpuscles (glomeruli) that play a crucial role in the filtering function of the kidney. Their size and density are important indicators of the health ...

A new research paper was published in Aging's Volume 15, Issue 14, entitled, “Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span.” ...

Injury of podocytes, if recognized at all, has been considered a late consequence caused by increasing proteinuria rather than an event inciting diabetic nephropathy.

Abatacept (CTLA-4–Ig) is an inhibitor of the T-cell costimulatory molecule B7-1 (CD80). 3 B7-1 is induced in podocytes in various animal models of proteinuria. 4 Podocyte B7-1 expression is not ...

More information: Natalya Kaverina et al, Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span, Aging (2023). DOI: 10.18632/aging.204897 ...

The results show that high blood pressure can lead to abnormalities in the podocytes, specialized cells in the renal filter, even without other pre-existing conditions such as diabetes.

The gene therapy, called PS-002, uses a modified virus to treat kidney cells called podocytes. Administration of PS-002 in a mouse model of IgA nephropathy reduced signs of kidney dysfunction, ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, “Inhibiting NLRP3 signaling in aging ...