Moreover, the function of transition zone proteins as gatekeepers at the ciliary base is challenged by the recent observation that plasma membrane proteins are excluded from primary cilia through ...

Primary cilia are hair-like, ... A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat. Cell Biol. 14, 61–72 (2012).

The resulting image reveals the richness of the surface of a pancreatic islet cell. Emerging from the microvilli-covered surface is a lone few microns-long primary cilium. Circular rings around its ...

Each cilium had a volume of about 0.15 μm 3, which is 5,000 times less than the corresponding cell.Furthermore, each cilia had a surface area of 3.05 μm 2, which is about 200 times less than the ...

By contrast, cells also contain a single, nonmotile cilium known as the primary cilium. Its presence on cells has been known for more than a century, but many believed it was a functionless ...

We identified 7 MKS and MKS-like proteins, and 2 NPHP proteins that all localise to a specific ciliary sub-compartment at the base of C. elegans sensory cilia called the transition zone.

A respiratory ciliopathy that can commonly occur in combination with alterations in other tissues with motile cilia is primary ciliary dyskinesia (PCD). However, in some families, this pathology ...

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Scientists performed association studies of 16,874 common genetic variants across 122 ciliary genes with 12 quantifiable laboratory traits characteristic of ciliopathy syndromes in 452,593 ...