Synopsis A temperature‐sensitive mutation in C. elegans CHE ‐3, the orthologue of mammalian DYNC 2H1, reveals a role for the intraflagellar transport (IFT) retrograde dynein motor in anterograde IFT ...

Many cells in our body have a single primary cilium, a micrometer-long, hair-like organelle protruding from the cell surface that transmits cellular signals. Cilia are important for regulating ...

The study, in collaboration with researchers from the lab of Prof. Ludo Van Den Bosch at VIB-KU Leuven, revealed that mutations in C21orf2 impair the formation and structure of primary cilia.

Malfunctions of tiny cell extensions (primary cilia*) in the beta cells of the pancreas may be a cause of type 2 diabetes. Little is known about the structure and function of these cilia. An ...

Primary cilia restrict autoinflammation by mediating PD-L1 expression Peer-Reviewed Publication Science China Press ...

Ciliopathies are rare diseases in which the formation or function of cilia, cylindrical-shaped extensions found on the surface of many cells, is altered. There is a high degree of ciliary ...

More information: Noelia Baz-Redón et al, Primary Ciliary Dyskinesia and Retinitis Pigmentosa: Novel RPGR Variant and Possible Modifier Gene, Cells (2024). DOI: 10.3390/cells13060524 ...

The primary cilium is an antenna-like structure of the plasma membrane, which is composed of the basal body, the transition zone, and the axoneme. Primary cilia contain receptors and channels that ...

The length of the primary cilia can vary and is tied to the healing process of a wound. The shorter the length of the cilia, the shorter the wound-healing time appears to be.

Each cilium had a volume of about 0.15 μm 3, which is 5,000 times less than the corresponding cell. Furthermore, each cilia had a surface area of 3.05 μm 2, which is about 200 times less than ...