The resulting image reveals the richness of the surface of a pancreatic islet cell. Emerging from the microvilli-covered surface is a lone few microns-long primary cilium. Circular rings around its ...

Gerhardt, C. et al. The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium. J. Cell Biol. 210, 115–133 (2015) Article CAS Google Scholar ...

By contrast, cells also contain a single, nonmotile cilium known as the primary cilium. Its presence on cells has been known for more than a century, but many believed it was a functionless ...

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A respiratory ciliopathy that can commonly occur in combination with alterations in other tissues with motile cilia is primary ciliary dyskinesia (PCD). However, in some families, this pathology ...

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis. The Journal of Cell Biology , 2011; 192 (6): 1023 DOI ...

Scientists performed association studies of 16,874 common genetic variants across 122 ciliary genes with 12 quantifiable laboratory traits characteristic of ciliopathy syndromes in 452,593 ...