A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...

Reactivation of the cyclin-dependent kinase inhibitor gene p15 in myelodysplastic syndromes and leukemias, which is silenced by promoter methylation, has been observed. 91 Although epigenetic ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Profiling promoter DNA methylation in the human genome. To determine the methylation status for a comprehensive set of human promoters, we enriched methylated DNA from human primary fibroblasts ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

Two promoter regions "face" each other, both of which initiate transcription. This so-called convergent transcription resembles a genomic ghost ride and was long considered an obstacle to gene ...

Characterizing gene promoters and promoter–terminator combinations is crucial for maximizing the benefits of bioengineering applications in plants. However, traditional methods of identifying ...

Investing.com -- Klotho Neurosciences, Inc. (NASDAQ: KLTO) stock surged 22% after the company announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to its ...

DNA contains genetic material called promoters, which essentially switch genes on and off. Because DNA is twisted and coiled in a 3D shape, these promoters can control genes that are located far ...

Decoding plant gene expression: A deep dive into promoters and terminators for advanced bioengineering. In high-precision bioengineering and synthetic biology, the fine-tuning of gene expression ...

In head-to-head comparisons, the new promoters outperformed the widely used GRK1 promoter in both expression strength and specificity. “This study addresses one of the biggest hurdles in IRD treatment ...