A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...

This article reviews the mechanisms of gene silencing in cancer and clinical applications of this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key event in the develo ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

The DNA segments of convergent promoters have been exceptionally well preserved in evolution and still show high similarity between different vertebrate species.

Characterizing gene promoters and promoter–terminator combinations is crucial for maximizing the benefits of bioengineering applications in plants. However, traditional methods of ...

A new study suggests that mutations in regions of the genome that help control gene activity may influence the development of autism.

At specific places called promoters, a complex molecular machinery starts transcribing DNA sequences into mRNA. Interestingly, most genes contain multiple possible sites where transcription can start ...

Decoding plant gene expression: A deep dive into promoters and terminators for advanced bioengineering In high-precision bioengineering and synthetic biology, the fine-tuning of gene expression at ...

Researchers have developed novel promoters that drive strong and specific gene expression in rod and cone photoreceptors in mid-to-late stages of disease, potentially offering new and improved options ...

What are Promoters and Enhancers? The genome contains a large number of non-coding DNA regulatory elements, including silencers, insulators, promoters and enhancers, which play an important role in ...