In severe cases of tissue death, there’s a possibility of amputation. This is commonly performed on arms, legs, fingers, or toes . Calciphylaxis isn’t curable, but remission is possible.

This month, the Food and Drug Administration approved the first therapy for treatment of severe frostbite in the country. This month, ...

The FDA on Wednesday approved the first medication injection to treat severe frostbite. Aurlumyn, which has the active ingredient iloprost, reduces the risk of finger or toe amputation, the FDA said.

The Food and Drug Administration this month approved the first-ever medication to treat severe frostbite in adults, a move that could reduce the risk of amputations from exposure. The injectable ...

Sixteen consecutive below-knee amputations were carried out in 15 patients because of actual or impending gangrene of the foot. The gangrenous areas extended to the heel in 5 limbs, but in no ...

Cynthia Elford loves to travel and hike, but a few years ago, her Type 1 diabetes made getting around nearly impossible. By 2018, the Pennsylvania grandmother faced the possibility of losing her ...

One of them, calciphylaxis, typically affects patients with end-stage, advanced kidney disease. It is a condition characterized by severe, painful and non-healing skin ulcers with no known cure.

The first time Dr. Peter Hackett saw a patient with frostbite, the man died from his wounds. It was in Chicago in 1971, and the man had gotten drunk and passed out in the snow, his fingers so froze… ...

Activation and targetability of TYMP–IL-6–TF signaling in the skin microenvironment in uremic calciphylaxis. Science Translational Medicine , 2025; 17 (795) DOI: 10.1126/scitranslmed.adn5772 ...