This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

Partnered Assets: SIRPα antagonists BI 765063 and BI 770371, an improved next generation SIRPα inhibitor, developed in partnership with Boehringer Ingelheim: Rapid Oral Abstracts of the Phase 1 ...

Partnered Assets: SIRPα antagonists BI 765063 and BI 770371, an improved next generation SIRPα inhibitor, developed in partnership with Boehringer Ingelheim: Rapid Oral Abstracts of the Phase 1 ...

Biohaven (BHVN) announced that it will present 13 abstracts at the 2025 American ... TRPM3 antagonism, TYK2/JAK1 inhibition, and glutamate modulation. Irfan Qureshi, M.D., Chief Medical Officer ...

which is a known mechanism-based inhibitor of CYP2C8 that leads to clinical DDIs with the substrates of CYP2C8. For example, the co-administration of gemfibrozil with the CYP2C8 substrate pioglitazone ...

Aftab, Lisa D. Belmont, Jae H. Chang. XL495 is a potent, selective, and orally bioavailable inhibitor of PKMYT1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual ...

Introduction: Cardiac fibrosis is one of the major pathophysiologic features of ischemic cardiac disorders and substantial evidence has shown that cardiac fibroblasts and their activated form ...

Despite this mounting body of evidence, the mechanisms underpinning saccharin-mediated growth inhibition in bacteria remain unexplored. In this work, we provide direct evidence for the first time that ...

Viability was assessed by performing XTT-assay to determine the effect of BRD9 inhibition in TGCT cell lines. FACS analysis was used to display changes in cell cycle distribution as well as apoptosis.

School of Biological Sciences and Biotechnology, Graduate School, Chonnam National University, Gwangju 61186, Republic of Korea Institute of Synthetic Biology for Carbon Neutralization, Chonnam ...