We suggest that T-cell-mediated cytotoxicity contributes to the destruction of platelets in ITP and that this is inhibited by the upregulation of KIRs, causing remission.

T-cell receptor (TCR) stimulation is the major cause of T lymphocyte exhaustion, with exhausted (T ex) cells constituting a unique cytotoxic subset. T ex cells produce lower levels of cytokines ...

Effect of KROS 101, a small molecule GITR ligand agonist, on T effector cells, T reg cells and intratumoral CD8 T cell cytotoxicity. Phase 1 study of DK210 (EGFR), a tumor-targeted IL2 x IL10 dual ...

CND261 is a bispecific antibody designed to target CD20 on B-cells and CD3 on T-cells, enabling T-cell mediated cytotoxicity against CD20-expressing B-cells.

New research reveals the mechanical processes used by T cells to kill cancer cells more efficiently. As a part of our immune defences, cytotoxic T cells -- or killer T cells -- seek out and ...

The study findings showed that highly activated and cytotoxic clusters of differentiation 4+ T lymphocyte responses might contribute to cell-mediated host tissue injury and COVID-19 progression.

AbbVie has agreed to buy Capstan Therapeutics for up to $2.1 billion, expanding its pipeline with a potential first-in-class ...

This webinar will be hosted live and available on-demand. Thursday, January 25, 2024 2:30-4:00 PM Eastern Time. B cells are the classical shield bearers of immune system memory, but memory T cell ...

These cytokines can damage the target cell directly or help activate “killer” T cells and macrophages. CD8+ killer T cells, also called cytotoxic T cells, perform direct lysis of target cells, while ...