The region flanking the central core may also contain the PsbS protein 2 but no attempt has been made to model this four-transmembrane helical protein into the map.

In 1977, the Nobel Prize in Physiology or Medicine was awarded to Roger Guillemin and Andrew Schally for their discovery and synthesis of gonadotropin-releasing hormone (GnRH), a key regulator of ...

The etiology of Alzheimer’s disease depends on the relative abundance of different amyloid-β (Aβ) peptide species. These peptides are produced by sequential proteolytic cleavage within the ...

OSAKA, Japan & BOSTON, MA, USA I June 23, 2025 I Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan; President and COO: Toichi Takino; “Ono”) and ...

Mechanistic discrepancies between species highlights the limitations of mouse models in advancing STING inhibition drugs for various diseases.

Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.

Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to both innate and adaptive immunity for host defence1,2,3. These receptors share a conserved ...

In 1977, the Nobel Prize in Physiology or Medicine was awarded to Roger Guillemin and Andrew Schally for their discovery and synthesis of ...

Europe frets about US retreating from region ahead of NATO By Andrea Palasciano, Michael Nienaber and Natalia Drozdiak Bloomberg, Updated June 22, 2025, 4:23 p.m.

New protein-design & engineering solution enables the first step in Dotmatics' end-to-end scientific intelligence vision—accelerating multimodal R&D with connected, data-driven workflows ...