Oncogenic YAP accelerates S-phase entry by shortening G1, leading to replication stress and sensitivity to CHK1 inhibition.

Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood ...

Abstract Arteriogenesis and wound healing are largely monocyte- and VEGFR1-dependent. VEGFR-1 intracellular signaling pathways were identified and characterized in primary human monocytes. PI-3K ...

Abstract Two signaling receptors for vascular endothelial growth factor (VEGF) in the vasculature are known with not yet well-understood roles in collateral vessel growth (arteriogenesis). In this ...

Macrophage polarization to M1 or M2 phenotypes has distinct metabolic requirements, in which the mechanistic target of rapamycin complex 1 (mTORC1) pathway plays a key role (Kang et al., 2018). mTORC1 ...

Vascular endothelial growth factor receptor-3 (VEGFR-3) is known to participate in tumorigenesis and lymphangiogenesis, and as such, has the potential to serve as a molecular target for cancer therapy ...

Potential therapeutic compounds were explored by using Cmap algorithm. Results: HIF-1 signaling pathway is a common key pathway for aneurysms, atherosclerosis and SARS-CoV-2 infection. Intercellular ...

1 Medical College, Guizhou University, Guiyang, China 2 Department of Oral and Maxillofacial Surgery, Guizhou Provincial People's Hospital, Guiyang, China 3 Department of Urology, Guizhou Provincial ...

Macrophage polarization has been implicated in the pathogenesis of obesity and type 2 diabetes, which are recognized as chronic proinflammatory diseases. This study investigated that high level of ...